Bone marrow transplantation (BMT) is a medical procedure that offers the potential for a complete cure of a patient's cancer, but it also introduces risks for severe psychological, interpersonal, financial and physical impairment. While the survival rate for BMT continues to rise, little is known about how this arduous and demanding treatment procedure affects the quality of lives of recipients and adjustment of survivors. A prospective longitudinal cohort design (total number of patients equal about 425) is proposed to follow groups of bone marrow transplant recipient survivors over time (up to 24 months). Complete illness history and psychosocial status will be assessed one month before BMT. New patients will enter the study at approximately the rate of 8 to 9 per month; to meet the target sample size of 425, new cases will be accepted for 51 months. Interviews will be conducted with patients at The Johns Hopkins Hospital Oncology Center before their transplants and at intervals post-BMT of 3, 6, 12, 18, and 24 months. The proposed study has both descriptive and predictive goals. First, the purpose is to describe the experience of bone marrow transplantation and how it affects the lives of recipients; and second, the research will examine the relationships between the psychological, social, economic, and health resources of the patients and their subsequent adjustment and life satisfaction. In addition to information obtained by self-report from the patient, data will also be obtained from a family member, caregivers, and medical and social service records. Statistical analyses employed will be those appropriate to a cohort-sequential, multivariable, multiwave model with structured means.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Public Health
United States
Zip Code
Baker, F; Marcellus, D; Zabora, J et al. (1997) Psychological distress among adult patients being evaluated for bone marrow transplantation. Psychosomatics 38:10-9
Somerfield, M R; Curbow, B; Wingard, J R et al. (1996) Coping with the physical and psychosocial sequelae of bone marrow transplantation among long-term survivors. J Behav Med 19:163-84
Baker, F; Wingard, J R; Curbow, B et al. (1994) Quality of life of bone marrow transplant long-term survivors. Bone Marrow Transplant 13:589-96
Curbow, B; Somerfield, M R; Baker, F et al. (1993) Personal changes, dispositional optimism, and psychological adjustment to bone marrow transplantation. J Behav Med 16:423-43
Wingard, J R; Plotnick, L P; Freemer, C S et al. (1992) Growth in children after bone marrow transplantation: busulfan plus cyclophosphamide versus cyclophosphamide plus total body irradiation. Blood 79:1068-73
Wingard, J R; Curbow, B; Baker, F et al. (1992) Sexual satisfaction in survivors of bone marrow transplantation. Bone Marrow Transplant 9:185-90
Somerfield, M; Curbow, B (1992) Methodological issues and research strategies in the study of coping with cancer. Soc Sci Med 34:1203-16
Wingard, J R; Curbow, B; Baker, F et al. (1991) Health, functional status, and employment of adult survivors of bone marrow transplantation. Ann Intern Med 114:113-8
Baker, F; Curbow, B; Wingard, J R (1991) Role retention and quality of life of bone marrow transplant survivors. Soc Sci Med 32:697-704
Curbow, B; Somerfield, M; Legro, M et al. (1990) Self-concept and cancer in adults: theoretical and methodological issues. Soc Sci Med 31:115-28