Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA049540-03
Application #
3193716
Study Section
Experimental Virology Study Section (EVR)
Project Start
1989-05-01
Project End
1994-04-30
Budget Start
1991-02-22
Budget End
1991-04-30
Support Year
3
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Crooks, D; Kil, S J; McCaffery, J M et al. (2000) E3-13.7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes. Mol Biol Cell 11:3559-72
Kil, S J; Carlin, C (2000) EGF receptor residues leu(679), leu(680) mediate selective sorting of ligand-receptor complexes in early endosomal compartments. J Cell Physiol 185:47-60
Kil, S J; Hobert, M; Carlin, C (1999) A leucine-based determinant in the epidermal growth factor receptor juxtamembrane domain is required for the efficient transport of ligand-receptor complexes to lysosomes. J Biol Chem 274:3141-50
Hobert, M E; Kil, S J; Medof, M E et al. (1997) The cytoplasmic juxtamembrane domain of the epidermal growth factor receptor contains a novel autonomous basolateral sorting determinant. J Biol Chem 272:32901-9
Stewart, A R; Tollefson, A E; Krajcsi, P et al. (1995) The adenovirus E3 10.4K and 14.5K proteins, which function to prevent cytolysis by tumor necrosis factor and to down-regulate the epidermal growth factor receptor, are localized in the plasma membrane. J Virol 69:172-81
Wold, W S; Tollefson, A E; Hermiston, T W (1995) E3 transcription unit of adenovirus. Curr Top Microbiol Immunol 199 ( Pt 1):237-74
Wold, W S; Hermiston, T W; Tollefson, A E (1994) Adenovirus proteins that subvert host defenses. Trends Microbiol 2:437-43
Hoffman, P; Carlin, C (1994) Adenovirus E3 protein causes constitutively internalized epidermal growth factor receptors to accumulate in a prelysosomal compartment, resulting in enhanced degradation. Mol Cell Biol 14:3695-706
Kuivinen, E; Hoffman, B L; Hoffman, P A et al. (1993) Structurally related class I and class II receptor protein tyrosine kinases are down-regulated by the same E3 protein coded for by human group C adenoviruses. J Cell Biol 120:1271-9
Hoffman, B L; Takishima, K; Rosner, M R et al. (1993) Adenovirus and protein kinase C have distinct molecular requirements for regulating epidermal growth factor receptor trafficking. J Cell Physiol 157:535-43

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