This project will develop a new imaging technique which improves the localization and the accuracy and precision of in vivo measurements of single-photon radiopharmaceutical. The project will incorporate a medical imaging system (X-SPELT) which uses adjacent conventional CT and SPELT imaging systems for correlating emission-based functional data and anatomical data from a coregistered x-ray transmission image. This proposal encompasses 4 specific aims. (1) We will develop techniques to compensate the radionuclide data for the effects of the geometric response of the SPELT system including (a) quantifying the radionuclide data with regions of interest defined on the CT image, and (b) defining recovery coefficients with structural information from the CT image to compensate the SPELT image for partial volume errors, and (c) incorporating structural information directly with the SPELT reconstruction algorithm. (2) We will develop scatter distribution using a technique which incorporates structural information from the CT-derived attenuation map, and compare it against conventional scatter correctin techniques. (3) Phantom experiments of tumor and myocardial perfusion imaging will be performed to evaluate the compensation techniques developed under Specific Aim 1 and 2, under experimental conditions which include the combined effects of photon attenuation, scatter radiation, noise, and partial volume effects. (4) Finally, the accuracy and precision of X-SPELT system will be determined for measurement of Tc-99m-MIBI uptake in a porcine model of myocardial perfusion to test the hypothesis that CT scans can be used to assess myocardial wall thickness to derive parameters to compensate the radionuclide data for partial volume effects, and to correct the correlated images for errors contributed by scattered radiation. These studies will evaluate the performance of the emission-transmission imaging for quantative radionuclide studies using Monte Carlo computer simulation, phantom studies, and experimental measurements in animals, with the intermediate goal of improving radionuclide assessments of myocardial perfusion, and with the long-term goal of applying these techniques to improve assessments of myocardial perfusion and tumor dosimetry in human patients obtained with single-photon radionclides.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050539-09
Application #
2894811
Study Section
Special Emphasis Panel (ZRG7-DMG (01))
Program Officer
Menkens, Anne E
Project Start
1989-07-10
Project End
2001-04-30
Budget Start
1999-05-01
Budget End
2001-04-30
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Da Silva, A J; Tang, H R; Wong, K H et al. (2001) Absolute quantification of regional myocardial uptake of 99mTc-sestamibi with SPECT: experimental validation in a porcine model. J Nucl Med 42:772-9
Brown, J K; Tang, H R; Hattner, R S et al. (2000) Intrinsic dual-energy processing of myocardial perfusion images. J Nucl Med 41:1287-97
LaCroix, K J; Tsui, B M; Hasegawa, B H (1998) A comparison of 180 degrees and 360 degrees acquisition for attenuation-compensated thallium-201 SPECT images. J Nucl Med 39:562-74
Kalki, K; Blankespoor, S C; Brown, J K et al. (1997) Myocardial perfusion imaging with a combined x-ray CT and SPECT system. J Nucl Med 38:1535-40
Heanue, J A; Brown, J K; Tang, H R et al. (1996) A bound on the energy resolution required for quantitative SPECT. Med Phys 23:169-73
Wu, X; Brown, J K; Kalki, K et al. (1996) Characterization and correction of pulse pile-up in simultaneous emission-transmission computed tomography. Med Phys 23:569-75
Brown, J K; Hasegawa, B H; Lang, T F (1994) Iterative concurrent reconstruction algorithms for emission computed tomography. Phys Med Biol 39:1113-32
Liew, S C; Hasegawa, B H; Brown, J K et al. (1993) Noise propagation in SPECT images reconstructed using an iterative maximum-likelihood algorithm. Phys Med Biol 38:1713-26
Lang, T F; Hasegawa, B H; Liew, S C et al. (1992) Description of a prototype emission-transmission computed tomography imaging system. J Nucl Med 33:1881-7
Gingold, E L; Hasegawa, B H (1992) Systematic bias in basis material decomposition applied to quantitative dual-energy x-ray imaging. Med Phys 19:25-33

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