Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050585-07
Application #
2093856
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1989-07-17
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Cormier, R T; Bilger, A; Lillich, A J et al. (2000) The Mom1AKR intestinal tumor resistance region consists of Pla2g2a and a locus distal to D4Mit64. Oncogene 19:3182-92
Cormier, R T; Dove, W F (2000) Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele. Cancer Res 60:3965-70
Gould, K A; Dove, W F (1998) Analysis of the Mom1 modifier of intestinal neoplasia in mice. Exp Lung Res 24:437-53
Shoemaker, A R; Moser, A R; Midgley, C A et al. (1998) A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice. Proc Natl Acad Sci U S A 95:10826-31
Shoemaker, A R; Luongo, C; Moser, A R et al. (1997) Somatic mutational mechanisms involved in intestinal tumor formation in Min mice. Cancer Res 57:1999-2006
Cormier, R T; Hong, K H; Halberg, R B et al. (1997) Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 17:88-91
Dove, W F; Clipson, L; Gould, K A et al. (1997) Intestinal neoplasia in the ApcMin mouse: independence from the microbial and natural killer (beige locus) status. Cancer Res 57:812-4
Shoemaker, A R; Gould, K A; Luongo, C et al. (1997) Studies of neoplasia in the Min mouse. Biochim Biophys Acta 1332:F25-48
Merritt, A J; Gould, K A; Dove, W F (1997) Polyclonal structure of intestinal adenomas in ApcMin/+ mice with concomitant loss of Apc+ from all tumor lineages. Proc Natl Acad Sci U S A 94:13927-31
Bilger, A; Shoemaker, A R; Gould, K A et al. (1996) Manipulation of the mouse germline in the study of Min-induced neoplasia. Semin Cancer Biol 7:249-60

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