Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050694-05
Application #
2093938
Study Section
Pathology B Study Section (PTHB)
Project Start
1991-02-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Schwartz, A G; Siegfried, J M; Weiss, L (1999) Familial aggregation of breast cancer with early onset lung cancer. Genet Epidemiol 17:274-84
Gealy, R; Zhang, L; Siegfried, J M et al. (1999) Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women. Cancer Epidemiol Biomarkers Prev 8:297-302
Siegfried, J M; Krishnamachary, N; Gaither Davis, A et al. (1999) Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer. Pulm Pharmacol Ther 12:291-302
Siegfried, J M (1998) Biology and chemoprevention of lung cancer. Chest 113:40S-45S
Siegfried, J M; Weissfeld, L A; Singh-Kaw, P et al. (1997) Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer. Cancer Res 57:433-9
Siegfried, J M; DeMichele, M A; Hunt, J D et al. (1997) Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides. Am J Respir Crit Care Med 156:358-66
Siegfried, J M; Davis, A L; Testa, J R et al. (1994) Ability to culture resectable non-small cell lung carcinomas is correlated with recurrence. Ann Thorac Surg 58:662-6;discussion 667
DeMichele, M A; Davis, A L; Hunt, J D et al. (1994) Expression of mRNA for three bombesin receptor subtypes in human bronchial epithelial cells. Am J Respir Cell Mol Biol 11:66-74
Shridhar, V; Siegfried, J; Hunt, J et al. (1994) Genetic instability of microsatellite sequences in many non-small cell lung carcinomas. Cancer Res 54:2084-7
Testa, J R; Siegfried, J M; Liu, Z et al. (1994) Cytogenetic analysis of 63 non-small cell lung carcinomas: recurrent chromosome alterations amid frequent and widespread genomic upheaval. Genes Chromosomes Cancer 11:178-94

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