Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA051025-04
Application #
2094072
Study Section
Pathology B Study Section (PTHB)
Project Start
1992-07-01
Project End
1998-05-31
Budget Start
1995-06-15
Budget End
1998-05-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
East Carolina University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Greenville
State
NC
Country
United States
Zip Code
27858
Lehmann, Brian D; Paine, Matthew S; Brooks, Adam M et al. (2008) Senescence-associated exosome release from human prostate cancer cells. Cancer Res 68:7864-71
Franklin, Richard A; McCubrey, James A (2007) Polyphenols in breast cancer treatment. Cancer Biol Ther 6:62-3
McCubrey, James A; Franklin, Richard A (2006) Reactive oxygen intermediates and signaling through kinase pathways. Antioxid Redox Signal 8:1745-8
Franklin, Richard A; Rodriguez-Mora, Oswaldo G; Lahair, Michelle M et al. (2006) Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress. Antioxid Redox Signal 8:1807-17
Lahair, Michelle M; Howe, Christopher J; Rodriguez-Mora, Oswaldo et al. (2006) Molecular pathways leading to oxidative stress-induced phosphorylation of Akt. Antioxid Redox Signal 8:1749-56
McCubrey, James A; Lahair, Michelle M; Franklin, Richard A (2006) Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid Redox Signal 8:1775-89
Rodriguez-Mora, Oswaldo G; Lahair, Michelle M; Evans, Mark J et al. (2006) Inhibition of the CaM-kinases augments cell death in response to oxygen radicals and oxygen radical inducing cancer therapies in MCF-7 human breast cancer cells. Cancer Biol Ther 5:1022-30
McCubrey, James A; Lahair, Michelle M; Franklin, Richard A (2006) OSU-03012 in the treatment of glioblastoma. Mol Pharmacol 70:437-9
Konopleva, Marina; Shi, Yuexi; Steelman, Linda S et al. (2005) Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells. Cancer Res 65:9962-70
Rodriguez-Mora, Oswaldo G; LaHair, Michelle M; McCubrey, James A et al. (2005) Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells. Cancer Res 65:5408-16

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