Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA051972-06
Application #
2094496
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1990-04-01
Project End
1997-03-31
Budget Start
1995-04-01
Budget End
1997-03-31
Support Year
6
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Michigan State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
193247145
City
East Lansing
State
MI
Country
United States
Zip Code
48824
Meyer, E B; Wells, W W (1999) Thioltransferase overexpression increases resistance of MCF-7 cells to adriamycin. Free Radic Biol Med 26:770-6
Washburn, M P; Wells, W W (1997) Glutathione dependent reduction of alloxan to dialuric acid catalyzed by thioltransferase (glutaredoxin): a possible role for thioltransferase in alloxan toxicity. Free Radic Biol Med 23:563-70
Xu, D P; Wells, W W (1996) alpha-Lipoic acid dependent regeneration of ascorbic acid from dehydroascorbic acid in rat liver mitochondria. J Bioenerg Biomembr 28:77-85
Xu, D P; Washburn, M P; Sun, G P et al. (1996) Purification and characterization of a glutathione dependent dehydroascorbate reductase from human erythrocytes. Biochem Biophys Res Commun 221:117-21
Wells, W W; Rocque, P A; Xu, D P et al. (1995) Ascorbic acid and cell survival of adriamycin resistant and sensitive MCF-7 breast tumor cells. Free Radic Biol Med 18:699-708
Wells, W W; Xu, D P; Washburn, M P (1995) Glutathione: dehydroascorbate oxidoreductases. Methods Enzymol 252:30-8
Katti, S K; Robbins, A H; Yang, Y et al. (1995) Crystal structure of thioltransferase at 2.2 A resolution. Protein Sci 4:1998-2005
Wells, W W; Xu, D P (1994) Dehydroascorbate reduction. J Bioenerg Biomembr 26:369-77
Wells, W W; Yang, Y; Deits, T L et al. (1993) Thioltransferases. Adv Enzymol Relat Areas Mol Biol 66:149-201
Wells, W W; Rocque, P A; Xu, D P et al. (1991) Interactions of platinum complexes with thioltransferase(glutaredoxin), in vitro. Biochem Biophys Res Commun 180:735-41

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