Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA052108-04
Application #
3196889
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1990-07-01
Project End
1993-08-31
Budget Start
1993-05-01
Budget End
1993-08-31
Support Year
4
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Type
Schools of Medicine
DUNS #
201373169
City
New York
State
NY
Country
United States
Zip Code
10065
Espat, N J; Auffenberg, T; Rosenberg, J J et al. (1996) Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am J Physiol 271:R185-90
Rogy, M A; Oldenburg, H S; Coyle, S et al. (1996) Correlation between Acute Physiology and Chronic Health Evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis. Br J Surg 83:396-400
Espat, N J; Auffenberg, T; Abouhamze, A et al. (1996) A role for tumor necrosis factor-alpha in the increased mortality associated with Vibrio vulnificus infection in the presence of hepatic dysfunction. Ann Surg 223:428-33
Calvano, S E; van der Poll, T; Coyle, S M et al. (1996) Monocyte tumor necrosis factor receptor levels as a predictor of risk in human sepsis. Arch Surg 131:434-7
Pruitt, J H; Welborn, M B; Edwards, P D et al. (1996) Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome. Blood 87:3282-8
Jansen, P M; Boermeester, M A; Fischer, E et al. (1995) Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory-type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal ba Blood 86:1027-34
Van Zee, K J; Coyle, S M; Calvano, S E et al. (1995) Influence of IL-1 receptor blockade on the human response to endotoxemia. J Immunol 154:1499-507
Espat, N J; Moldawer, L L; Copeland 3rd, E M (1995) Cytokine-mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients. J Surg Oncol 58:77-82
van der Poll, T; Van Zee, K J; Endert, E et al. (1995) Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. J Clin Endocrinol Metab 80:1341-6
Rogy, M A; Auffenberg, T; Espat, N J et al. (1995) Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses. J Exp Med 181:2289-93

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