Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA052498-03S1
Application #
3197241
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Lomako, Joseph; Lomako, Wieslawa M; Carothers Carraway, Coralie A et al. (2010) Regulation of the membrane mucin Muc4 in corneal epithelial cells by proteosomal degradation and TGF-beta. J Cell Physiol 223:209-14
Kozloski, Goldi A; Carraway, Coralie A Carothers; Carraway, Kermit L (2010) Mechanistic and signaling analysis of Muc4-ErbB2 signaling module: new insights into the mechanism of ligand-independent ErbB2 activity. J Cell Physiol 224:649-57
Lomako, Wieslawa M; Lomako, Joseph; Soto, Pedro et al. (2009) TGFbeta regulation of membrane mucin Muc4 via proteosome degradation. J Cell Biochem 107:797-802
Carraway, Kermit L; Theodoropoulos, George; Kozloski, Goldi A et al. (2009) Muc4/MUC4 functions and regulation in cancer. Future Oncol 5:1631-40
Theodoropoulos, George; Carraway, Coralie A Carothers; Carraway, Kermit L (2009) MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury. J Cell Biochem 107:112-22
Workman, Heather C; Miller, Jamie K; Ingalla, Ellen Q et al. (2009) The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast Cancer Res 11:R70
Carraway, Kermit L; Kozloski, Goldi A (2009) Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights. F1000 Biol Rep 1:72
Theodoropoulos, George; Carraway, Kermit L (2007) Molecular signaling in the regulation of mucins. J Cell Biochem 102:1103-16
Jonckheere, Nicolas; Vincent, Audrey; Perrais, Michael et al. (2007) The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem 282:22638-50
Zhang, Jin; Yasin, Mohammad; Carraway, Coralie A Carothers et al. (2006) MUC4 expression and localization in gastrointestinal tract and skin of human embryos. Tissue Cell 38:271-5

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