Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA053491-03
Application #
2095359
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1997-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Maryland Baltimore
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Amstad, P A; Liu, H; Ichimiya, M et al. (2001) BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production. Redox Rep 6:351-62
Gu, Y; Desai, T; Gutierrez, P L et al. (2001) Alteration of DNA base excision repair enzymes hMYH and hOGG1 in hydrogen peroxide resistant transformed human breast cells. Med Sci Monit 7:861-8
Gutierrez, P L (2000) The metabolism of quinone-containing alkylating agents: free radical production and measurement. Front Biosci 5:D629-38
Li, B; Blough, N V; Gutierrez, P L (2000) Trace detection of hydroxyl radicals during the redox cycling of low concentrations of diaziquone: a new approach. Free Radic Biol Med 29:548-56
Li, B; Gutierrez, P L; Amstad, P et al. (1999) Hydroxyl radical production by mouse epidermal cell lines in the presence of quinone anti-cancer compounds. Chem Res Toxicol 12:1042-9
Li, B; Gutierrez, P L; Blough, N V (1999) Trace determination of hydroxyl radical using fluorescence detection. Methods Enzymol 300:202-16
Ngo, E O; Nutter, L M; Sura, T et al. (1998) Induction of p53 by the concerted actions of aziridine and quinone moieties of diaziquone. Chem Res Toxicol 11:360-8
Li, B; Gutierrez, P L; Blough, N V (1997) Trace determination of hydroxyl radical in biological systems. Anal Chem 69:4295-302
Lenehan, P F; Gutierrez, P L; Wagner, J L et al. (1995) Resistance to oxidants associated with elevated catalase activity in HL-60 leukemia cells that overexpress multidrug-resistance protein does not contribute to the resistance to daunorubicin manifested by these cells. Cancer Chemother Pharmacol 35:377-86
Gutierrez, P L; Siva, S (1995) Diaziquone-glutathione conjugates: characterization and mechanisms of formation. Chem Res Toxicol 8:455-64

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