Urocanic Acid, Sunlight & Immunity a Novel Interaction

Defabo, Edward C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 3R01CA053793-06S1
• Application #: 2356946
• Study Section: Surgery and Bioengineering Study Section (SB)
• Project Start: 1990-12-04
• Project End: 1998-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 6
• Fiscal Year: 1996

Institution

• Name: George Washington University
• Department: Dermatology
• Type: Schools of Medicine
• City: Washington
• State: DC
• Country: United States
• Zip Code: 20052

Publications

Bouscarel, B; Noonan, F; Ceryak, S et al. (1998) Regulation of stimulated cyclic AMP synthesis by urocanic acid. Photochem Photobiol 67:324-31

Ceryak, S; Bouscarel, B; Malavolti, M et al. (1998) Extrahepatic deposition and cytotoxicity of lithocholic acid: studies in two hamster models of hepatic failure and in cultured human fibroblasts. Hepatology 27:546-56

De Fabo, E C; Webber, L J; Ulman, E A et al. (1997) Dietary L-histidine regulates murine skin levels of trans-urocanic acid, an immune-regulating photoreceptor, with an unanticipated modulation: potential relevance to skin cancer. J Nutr 127:2158-64

Webber, L J; Whang, E; De Fabo, E C (1997) The effects of UVA-I (340-400 nm), UVA-II (320-340 nm) and UVA-I+II on the photoisomerization of urocanic acid in vivo. Photochem Photobiol 66:484-92

Phillips, T M; Kennedy, L M; De Fabo, E C (1997) Microdialysis-immunoaffinity capillary electrophoresis studies on neuropeptide-induced lymphocyte secretion. J Chromatogr B Biomed Sci Appl 697:101-9

Bouscarel, B; Ceryak, S; Gettys, T W et al. (1995) Alteration of cAMP-mediated hormonal responsiveness by bile acids in cells of nonhepatic origin. Am J Physiol 268:G908-16

Reilly, S K; De Fabo, E C (1991) Dietary histidine increases mouse skin urocanic acid levels and enhances UVB-induced immune suppression of contact hypersensitivity. Photochem Photobiol 53:431-8