Triplex Based Inhibition of Dhfr and Cyclin Dl

Miller, Donald M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 2R01CA054380-04
• Application #: 2095878
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1991-09-30
• Project End: 2001-02-28
• Budget Start: 1996-03-01
• Budget End: 1997-02-28
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: University of Alabama Birmingham
• Department: Internal Medicine/Medicine
• Type: Schools of Medicine
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Stewart, Delisha A; Xu, Xiaohua; Thomas, Shelia D et al. (2002) Acridine-modified, clamp-forming antisense oligonucleotides synergize with cisplatin to inhibit c-Myc expression and B16-F0 tumor progression. Nucleic Acids Res 30:2565-74

Stewart, D A; Thomas, S D; Mayfield, C A et al. (2001) Psoralen-modified clamp-forming antisense oligonucleotides reduce cellular c-Myc protein expression and B16-F0 proliferation. Nucleic Acids Res 29:4052-61

Kim, H G; Reddoch, J F; Mayfield, C et al. (1998) Inhibition of transcription of the human c-myc protooncogene by intermolecular triplex. Biochemistry 37:2299-304

Kim, H G; Miller, D M (1998) A novel triplex-forming oligonucleotide targeted to human cyclin D1 (bcl-1, proto-oncogene) promoter inhibits transcription in HeLa cells. Biochemistry 37:2666-72

Kim, H G; Miller, D M (1995) Inhibition of in vitro transcription by a triplex-forming oligonucleotide targeted to human c-myc P2 promoter. Biochemistry 34:8165-71