Cellular Interactions of 5-Fluorouracil and Interferon

Schwartz, Edward L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA054422-03
• Application #: 2095935
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1994-05-06
• Project End: 1997-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Montefiore Medical Center (Bronx, NY)
• City: New York
• State: NY
• Country: United States
• Zip Code: 10467

Publications

Hotchkiss, Kylie A; Ashton, Anthony W; Schwartz, Edward L (2003) Thymidine phosphorylase and 2-deoxyribose stimulate human endothelial cell migration by specific activation of the integrins alpha 5 beta 1 and alpha V beta 3. J Biol Chem 278:19272-9

Hotchkiss, Kylie A; Ashton, Anthony W; Klein, Robert S et al. (2003) Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration. Cancer Res 63:527-33

Zhu, Geng Hui; Schwartz, Edward L (2003) Expression of the angiogenic factor thymidine phosphorylase in THP-1 monocytes: induction by autocrine tumor necrosis factor-alpha and inhibition by aspirin. Mol Pharmacol 64:1251-8

Zhu, Geng Hui; Lenzi, Michelle; Schwartz, Edward L (2002) The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells. Oncogene 21:8477-85

Hotchkiss, Kylie A; Ashton, Anthony W; Mahmood, Radma et al. (2002) Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center. Mol Cancer Ther 1:1191-200

Klein, R S; Lenzi, M; Lim, T H et al. (2001) Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase. Biochem Pharmacol 62:1257-63