Cell Transformation by Insulin and Igfi Receptors

Wang, Lu-Hai

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA055054-05
• Application #: 2096289
• Study Section: Experimental Virology Study Section (EVR)
• Project Start: 1992-06-01
• Project End: 1998-03-31
• Budget Start: 1996-04-01
• Budget End: 1998-03-31
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: Mount Sinai School of Medicine
• Department: Microbiology/Immun/Virology
• Type: Schools of Medicine
• DUNS #: 114400633
• City: New York
• State: NY
• Country: United States
• Zip Code: 10029

Publications

Schlosshauer, Peter W; Li, Wei; Lin, Kai-Ti et al. (2009) Rapamycin by itself and additively in combination with carboplatin inhibits the growth of ovarian cancer cells. Gynecol Oncol 114:516-22

Uttamsingh, S; Bao, X; Nguyen, K T et al. (2008) Synergistic effect between EGF and TGF-beta1 in inducing oncogenic properties of intestinal epithelial cells. Oncogene 27:2626-34

Le, Maithao N; Kohanski, Ronald A; Wang, Lu-Hai et al. (2002) Dual mechanism of signal transducer and activator of transcription 5 activation by the insulin receptor. Mol Endocrinol 16:2764-79

Chan, J L; Lai, M; Wang, L H (1997) Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin, and insulin-like growth factor I receptors. J Biol Chem 272:146-53

Chen, J; Hanafusa, T; Wang, L H (1994) Ala-->Gly mutation in the putative catalytic loop confers temperature sensitivity on Ros, insulin receptor, and insulin-like growth factor I receptor protein-tyrosine kinases. Proc Natl Acad Sci U S A 91:321-5

Liu, D; Zong, C S; Wang, L H (1993) Distinctive effects of the carboxyl-terminal sequence of the insulin-like growth factor I receptor on its signaling functions. J Virol 67:6835-40