Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA055251-05S1
Application #
2647379
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1997-07-01
Project End
1999-01-31
Budget Start
1997-07-01
Budget End
1998-01-31
Support Year
5
Fiscal Year
1997
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Yang, Jun; Mager, Donald E; Straubinger, Robert M (2010) Comparison of two pharmacodynamic transduction models for the analysis of tumor therapeutic responses in model systems. AAPS J 12:1-10
Zhou, Rong; Mazurchuk, Richard V; Tamburlin, Judith H et al. (2010) Differential pharmacodynamic effects of paclitaxel formulations in an intracranial rat brain tumor model. J Pharmacol Exp Ther 332:479-88
Straubinger, Robert M; Krzyzanski, Wojciech; Francoforte, Crystal M et al. (2007) Applications of quantitative pharmacodynamic effect markers in drug target identification and therapy development. Anticancer Res 27:1237-46
Straubinger, Robert M; Arnold, Robert D; Zhou, Rong et al. (2004) Antivascular and antitumor activities of liposome-associated drugs. Anticancer Res 24:397-404
Fetterly, Gerald J; Straubinger, Robert M (2003) Pharmacokinetics of paclitaxel-containing liposomes in rats. AAPS PharmSci 5:E32
Fetterly, G J; Tamburlin, J M; Straubinger, R M (2001) Paclitaxel pharmacodynamics: application of a mechanism-based neutropenia model. Biopharm Drug Dispos 22:251-61
Campbell, R B; Balasubramanian, S V; Straubinger, R M (2001) Influence of cationic lipids on the stability and membrane properties of paclitaxel-containing liposomes. J Pharm Sci 90:1091-105
Campbell, R B; Balasubramanian, S V; Straubinger, R M (2001) Phospholipid-cationic lipid interactions: influences on membrane and vesicle properties. Biochim Biophys Acta 1512:27-39
Zhou, R; Balasubramanian, S V; Kahl, S B et al. (1999) Biopharmaceutics of boronated radiosensitizers: liposomal formulation of MnBOPP (manganese chelate of 2,4-(alpha, beta-dihydroxyethyl) deuterioporphyrin IX) and comparative toxicity in mice. J Pharm Sci 88:912-7
Mazurchuk, R; Zhou, R; Straubinger, R M et al. (1999) Functional magnetic resonance (fMR) imaging of a rat brain tumor model: implications for evaluation of tumor microvasculature and therapeutic response. Magn Reson Imaging 17:537-48

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