Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055254-06
Application #
2096476
Study Section
Special Emphasis Panel (ZRG3-MCHA (01))
Project Start
1991-07-01
Project End
2001-04-30
Budget Start
1996-07-09
Budget End
1997-04-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington State University
Department
Biochemistry
Type
Schools of Earth Sciences/Natur
DUNS #
041485301
City
Pullman
State
WA
Country
United States
Zip Code
99164
Guerra-Bubb, Jennifer; Croteau, Rodney; Williams, Robert M (2012) The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. Nat Prod Rep 29:683-96
Köksal, Mustafa; Jin, Yinghua; Coates, Robert M et al. (2011) Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature 469:116-20
Kaspera, Rüdiger; Cape, Jonathan L; Faraldos, Juan A et al. (2010) Synthesis and In Vitro Evaluation of Taxol oxetane ring D precursors. Tetrahedron Lett 51:2017-2019
Hampel, Daniela; Mau, Christopher J D; Croteau, Rodney B (2009) Taxol biosynthesis: Identification and characterization of two acetyl CoA:taxoid-O-acetyl transferases that divert pathway flux away from Taxol production. Arch Biochem Biophys 487:91-7
Ketchum, Raymond E B; Wherland, Lea; Croteau, Rodney B (2007) Stable transformation and long-term maintenance of transgenic Taxus cell suspension cultures. Plant Cell Rep 26:1025-33
Dejong, JingHong M; Liu, Yule; Bollon, Arthur P et al. (2006) Genetic engineering of taxol biosynthetic genes in Saccharomyces cerevisiae. Biotechnol Bioeng 93:212-24
Jennewein, Stefan; Park, Hangil; DeJong, Jinghong M et al. (2005) Coexpression in yeast of Taxus cytochrome P450 reductase with cytochrome P450 oxygenases involved in Taxol biosynthesis. Biotechnol Bioeng 89:588-98
Long, Robert M; Croteau, Rodney (2005) Preliminary assessment of the C13-side chain 2'-hydroxylase involved in taxol biosynthesis. Biochem Biophys Res Commun 338:410-7
Chau, MyDoanh; Walker, Kevin; Long, Robert et al. (2004) Regioselectivity of taxoid-O-acetyltransferases: heterologous expression and characterization of a new taxadien-5alpha-ol-O-acetyltransferase. Arch Biochem Biophys 430:237-46
Chau, MyDoanh; Croteau, Rodney (2004) Molecular cloning and characterization of a cytochrome P450 taxoid 2alpha-hydroxylase involved in Taxol biosynthesis. Arch Biochem Biophys 427:48-57

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