Antitumor Antibiotics - Duocarmycin

Boger, Dale L.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA055276-04
• Application #: 2096495
• Study Section: Bio-Organic and Natural Products Chemistry Study Section (BNP)
• Project Start: 1991-07-01
• Project End: 1995-10-31
• Budget Start: 1994-05-01
• Budget End: 1995-10-31
• Support Year: 4
• Fiscal Year: 1994

Institution

• Name: Scripps Research Institute
• City: La Jolla
• State: CA
• Country: United States
• Zip Code: 92037

Publications

Eis, P S; Smith, J A; Rydzewski, J M et al. (1997) High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA. J Mol Biol 272:237-52

Boger, D L; Johnson, D S; Palanki, M S et al. (1993) Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit. Bioorg Med Chem 1:27-38