Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA055339-06
Application #
2096559
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1991-02-01
Project End
2001-01-31
Budget Start
1996-04-26
Budget End
1997-01-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Wu, C L; Classon, M; Dyson, N et al. (1996) Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol 16:3698-706
Dulic, V; Kaufmann, W K; Wilson, S J et al. (1994) p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell 76:1013-23
Tsai, L H; Lees, E; Faha, B et al. (1993) The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene 8:1593-602
Faha, B; Harlow, E; Lees, E (1993) The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J Virol 67:2456-65
Lees, E M; Harlow, E (1993) Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol Cell Biol 13:1194-201
Faha, B; Ewen, M E; Tsai, L H et al. (1992) Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science 255:87-90
Lees, E; Faha, B; Dulic, V et al. (1992) Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev 6:1874-85
Dulic, V; Lees, E; Reed, S I (1992) Association of human cyclin E with a periodic G1-S phase protein kinase. Science 257:1958-61
Meyerson, M; Faha, B; Su, L K et al. (1991) The cyclin-dependent kinase family. Cold Spring Harb Symp Quant Biol 56:177-86