Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055547-05
Application #
2096681
Study Section
Cellular Biology and Physiology Subcommittee 1 (CBY)
Project Start
1992-03-01
Project End
1996-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
Serra-Pages, Carles; Streuli, Michel; Medley, Quintus G (2005) Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation. Biochemistry 44:15715-24
Medley, Quintus G; Buchbinder, Elizabeth G; Tachibana, Kouichi et al. (2003) Signaling between focal adhesion kinase and trio. J Biol Chem 278:13265-70
Wyszynski, Michael; Kim, Eunjoon; Dunah, Anthone W et al. (2002) Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Neuron 34:39-52
Seipel, K; O'Brien, S P; Iannotti, E et al. (2001) Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. J Cell Sci 114:389-99
Medley, Q G; Serra-Pages, C; Iannotti, E et al. (2000) The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain. J Biol Chem 275:36116-23
Kickhoefer, V A; Siva, A C; Kedersha, N L et al. (1999) The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose) polymerase. J Cell Biol 146:917-28
Seipel, K; Medley, Q G; Kedersha, N L et al. (1999) Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. J Cell Sci 112 ( Pt 12):1825-34
Serra-Pages, C; Medley, Q G; Tang, M et al. (1998) Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. J Biol Chem 273:15611-20
Taviaux, S; Diriong, S; Bellanger, J M et al. (1997) Assignment of TRIO, the Trio gene (PTPRF interacting) to human chromosome bands 5p 15.1-->p 14 by in situ hybridization. Cytogenet Cell Genet 76:107-8
Debant, A; Serra-Pages, C; Seipel, K et al. (1996) The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains. Proc Natl Acad Sci U S A 93:5466-71

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