Mechanism of Cytotoxicity of Topoisomerase II Poisons

Kaufmann, Scott H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA055642-03
• Application #: 3200151
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1992-03-05
• Project End: 1994-08-31
• Budget Start: 1994-03-01
• Budget End: 1994-08-31
• Support Year: 3
• Fiscal Year: 1994

Institution

• Name: Johns Hopkins University
• Type: Schools of Medicine
• DUNS #: 045911138
• City: Baltimore
• State: MD
• Country: United States
• Zip Code: 21218

Publications

Lazebnik, Y A; Takahashi, A; Poirier, G G et al. (1995) Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells. J Cell Sci Suppl 19:41-9

Kaufmann, S H; Desnoyers, S; Ottaviano, Y et al. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 53:3976-85