Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055659-04
Application #
2096776
Study Section
Radiation Study Section (RAD)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1995-02-10
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Riverside
Department
Zoology
Type
Schools of Earth Sciences/Natur
DUNS #
City
Riverside
State
CA
Country
United States
Zip Code
92521
Giver, C R; Grosovsky, A J (2000) Radiation specific patterns of loss of heterozygosity on chromosome 17q. Mutat Res 450:201-9
Smith, L E; Parks, K K; Hasegawa, L S et al. (1998) Targeted breakage of paracentromeric heterochromatin induces chromosomal instability. Mutagenesis 13:435-43
Dobo, K L; Eastmond, D A; Grosovsky, A J (1998) Sequence specific mutations induced by N-nitrosodimethylamine at two marker loci in metabolically competent human lymphoblastoid cells. Carcinogenesis 19:755-64
Dobo, K L; Eastmond, D A; Grosovsky, A J (1997) The influence of cellular apoptotic capacity on N-nitrosodimethylamine-induced loss of heterozygosity mutations in human cells. Carcinogenesis 18:1701-7
Giver, C R; Grosovsky, A J (1997) Single and coincident intragenic mutations attributable to gene conversion in a human cell line. Genetics 146:1429-39
Pongsaensook, P; Smith, L E; Grosovsky, A J (1997) Isolation of an APRT heterozygote from TK6 human lymphoblasts: predominance of multi-locus loss of heterozygosity among spontaneous APRT-mutants. Mutat Res 377:27-36
Grosovsky, A J; Parks, K K; Giver, C R et al. (1996) Clonal analysis of delayed karyotypic abnormalities and gene mutations in radiation-induced genetic instability. Mol Cell Biol 16:6252-62
Nelson, S L; Parks, K K; Grosovsky, A J (1996) Ionizing radiation signature mutations in human cell mutants induced by low-dose exposures. Mutagenesis 11:275-9
Dobo, K L; Giver, C R; Eastmond, D A et al. (1995) Extensive loss of heterozygosity accounts for differential mutation rate on chromosome 17q in human lymphoblasts. Mutagenesis 10:53-8
Nelson, S L; Jones, I M; Fuscoe, J C et al. (1995) Mapping the end points of large deletions affecting the hprt locus in human peripheral blood cells and cell lines. Radiat Res 141:2-10

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