Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA055728-06
Application #
2096843
Study Section
Special Emphasis Panel (ZRG4-PTHA (01))
Project Start
1991-05-01
Project End
2000-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Smith, J S; Wang, X Y; Qian, J et al. (2000) Amplification of the platelet-derived growth factor receptor-A (PDGFRA) gene occurs in oligodendrogliomas with grade IV anaplastic features. J Neuropathol Exp Neurol 59:495-503
Frederick, L; Eley, G; Wang, X Y et al. (2000) Analysis of genomic rearrangements associated with EGRFvIII expression suggests involvement of Alu repeat elements. Neuro Oncol 2:159-63
Frederick, L; Wang, X Y; Eley, G et al. (2000) Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 60:1383-7
Raffel, C; Frederick, L; O'Fallon, J R et al. (1999) Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin Cancer Res 5:4085-90
Bredel, M; Pollack, I F; Hamilton, R L et al. (1999) Epidermal growth factor receptor expression and gene amplification in high-grade non-brainstem gliomas of childhood. Clin Cancer Res 5:1786-92
James, C D; Galanis, E; Frederick, L et al. (1999) Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. Int J Oncol 15:547-53
Wang, X Y; Smith, D I; Liu, W et al. (1998) GBAS, a novel gene encoding a protein with tyrosine phosphorylation sites and a transmembrane domain, is co-amplified with EGFR. Genomics 49:448-51
Wang, X Y; Smith, D I; Frederick, L et al. (1998) Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences. Oncogene 16:191-5
Eley, G; Frederick, L; Wang, X Y et al. (1998) 3' end structure and rearrangements of EGFR in glioblastomas. Genes Chromosomes Cancer 23:248-54
Liu, W; Smith, D I; Rechtzigel, K J et al. (1998) Denaturing high performance liquid chromatography (DHPLC) used in the detection of germline and somatic mutations. Nucleic Acids Res 26:1396-400

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