The overall goal of this project is to identify breast cancer susceptibility genes and to elucidate how they interact with epidemiological risk factors to cause this malignancy. This work is geared towards the African-American population, which has been scarcely studied and has shown an increase in the incidence of breast cancer in recent times, especially in younger women. The project has four complementary components. The core component is a family study which will address for the first time the issue of interactions between genetic susceptibility and epidemiological risk factors of breast cancer in a hospital based series of family data. This will involve collecting systematically a sample of 250-300 families through all new breast cancer patients treated at Howard University Hospital. The recorded information will include: a detailed clinical and histological description of the tumor, the identification of the patient's first and second degree relatives. The familial analysis will be conducted by the relevant statistical models, to test for specific genetic hypotheses while accounting for various risk factors and other sources of familial covariation. The second component, a case/control study, using hospital, neighborhood, and sister controls, will determine the risk factors associated with breast cancer which are relevant to the African-American population. Comparisons will be made with risk factors already identified among Caucasians. The third component, loss of hererozygosity analysis in tumor/blood pairs from breast cancer patients, will identify chromosomal regions which may harbor breast cancer susceptibility genes. The las component involves the mapping of breast cancer genes by linkage analysis in multiple-case families. The chromosomal location of breast cancer genes and the understanding of how these genes interact with environment in tumorigenesis will have direct significance in counseling and prevention.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055772-03
Application #
2096884
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1991-09-30
Project End
1995-08-31
Budget Start
1993-09-01
Budget End
1995-08-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Howard University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
056282296
City
Washington
State
DC
Country
United States
Zip Code
20059
Chestukhin, Anton; Pfeffer, Christian; Milligan, Scott et al. (2003) Processing, localization, and requirement of human separase for normal anaphase progression. Proc Natl Acad Sci U S A 100:4574-9
Chaudru, Valerie; Laing, Amelia; Dunston, Georgia M et al. (2002) Interactions between genetic and reproductive factors in breast cancer risk in a population-based sample of African-American families. Genet Epidemiol 22:285-97
McDonald, Paige A Green; Williams, Rosemary; Dawkins, Fitzroy et al. (2002) Breast cancer survival in African American women: is alcohol consumption a prognostic indicator? Cancer Causes Control 13:543-9
Agurs-Collins, T; Adams-Campbell, L L; Kim, K S et al. (2000) Insulin-like growth factor-1 and breast cancer risk in postmenopausal African-American women. Cancer Detect Prev 24:199-206
Mefford, H C; Baumbach, L; Panguluri, R C et al. (1999) Evidence for a BRCA1 founder mutation in families of West African ancestry. Am J Hum Genet 65:575-8
Agurs-Collins, T; Kim, K S; Dunston, G M et al. (1998) Plasma lipid alterations in African-American women with breast cancer. J Cancer Res Clin Oncol 124:186-90
Adams-Campbell, L L; Kim, K S; Dunston, G et al. (1996) The relationship of body mass index to reproductive factors in pre- and postmenopausal African-American women with and without breast cancer. Obes Res 4:451-6
Schneider, B G; Pulitzer, D R; Brown, R D et al. (1995) Allelic imbalance in gastric cancer: an affected site on chromosome arm 3p. Genes Chromosomes Cancer 13:263-71
O'Connell, P; Albertsen, H; Matsunami, N et al. (1994) A radiation hybrid map of the BRCA1 region. Am J Hum Genet 54:526-34
Amos, C I; Laing, A E (1993) A comparison of univariate and multivariate tests for genetic linkage. Genet Epidemiol 10:671-6

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