Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA056407-03S1
Application #
2097290
Study Section
Special Emphasis Panel (SRC (40))
Project Start
1992-05-01
Project End
1996-05-31
Budget Start
1994-05-01
Budget End
1996-05-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Southern California
Department
Biochemistry
Type
Other Domestic Higher Education
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Bentham, G; Wolfreys, A M; Liu, Y et al. (1999) Frequencies of hprt(-) mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records. Mutagenesis 14:527-32
Liu, Y; Cortopassi, G; Steingrimsdottir, H et al. (1997) Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes. Environ Mol Mutagen 29:36-45
Cortopassi, G; Liu, Y; Hutchin, T (1996) Degeneration of human oncogenes and mitochondrial genes occurs in cells that exhibit age-related pathology. Exp Gerontol 31:253-65
Cole, J; Green, M H; Bridges, B A et al. (1996) Lack of evidence for an association between the frequency of mutants or translocations in circulating lymphocytes and exposure to radon gas in the home. Radiat Res 145:61-9
Cortopassi, G; Liu, Y (1995) Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology. Mutat Res 338:151-9
Bell, D A; Liu, Y; Cortopassi, G A (1995) Occurrence of bcl-2 oncogene translocation with increased frequency in the peripheral blood of heavy smokers. J Natl Cancer Inst 87:223-4
Cortopassi, G; Hutchin, T (1994) A molecular and cellular hypothesis for aminoglycoside-induced deafness. Hear Res 78:27-30
Liu, Y; Hernandez, A M; Shibata, D et al. (1994) BCL2 translocation frequency rises with age in humans. Proc Natl Acad Sci U S A 91:8910-4
Hutchin, T; Cortopassi, G (1994) Proposed molecular and cellular mechanism for aminoglycoside ototoxicity. Antimicrob Agents Chemother 38:2517-20