Tumor hypoxia is an obstacle to optimal treatment with radiotherapy and for many chemotherapeutic agents. Experimentally, it has been found that perfluorocarbon - oxygen breathing - can correct tumor hypoxia and that such treatment can substantially improve the anti-tumor effect of radiotherapy and chemotherapy. Using the Eppendorf pO2 histograph, we plan to evaluate human tumors, specifically head and neck cancer, metastatic breast cancer, and metastatic melanoma for hypoxia. A phase I - phase II clinical pharmacologic study of fluosol-oxygen will be conducted in these patients wherein a critical endpoint will be correction of hypoxia. Finally, the patients will be treated with chemotherapy during the perfluorocarbon oxygen breathing. If the aforementioned studies prove positive, appropriate phase II and phase III studies will be conducted. In parallel with the above, studies will be conducted in a rat transplanted breast cancer model to provide leads and course correction for the clinical study, as well as to provide more fundamental information with respect to hypoxia and its perturbation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA056501-01
Application #
3200856
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1992-09-30
Project End
1996-07-31
Budget Start
1992-09-30
Budget End
1993-07-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
149617367
City
Boston
State
MA
Country
United States
Zip Code
02215
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Teicher, B A; Dupuis, N P; Emi, Y et al. (1995) Increased efficacy of chemo- and radio-therapy by a hemoglobin solution in the 9L gliosarcoma. In Vivo 9:11-8
Teicher, B A; Holden, S A; Ara, G et al. (1995) Influence of an anti-angiogenic treatment on 9L gliosarcoma: oxygenation and response to cytotoxic therapy. Int J Cancer 61:732-7
Dupuis, N P; Kusumoto, T; Robinson, M F et al. (1995) Restoration of tumor oxygenation after cytotoxic therapy by a perflubron emulsion/carbogen breathing. Artif Cells Blood Substit Immobil Biotechnol 23:423-9