We propose to investigate the following three important statistical problems arising in cancer studies. The results from-this research would be quite useful in analyzing cancer studies. These problems are: 1) Semi-parametric methods for the linear regression model with censored data. We will study efficient numerical algorithms to implement the rank linear regression methods proposed by Wei, Ying, and Lin (1990) with censored data; investigate the appropriateness of the large sample theory for their procedures with practical sample sizes; generalize their methods to the multivariate failure time data; study procedures for monitoring cancer survival trials; explore linear regression methods for highly stratified failure time observations; and study the Buckley-James procedures. 2) Lack-of-fit test for regression models. We will study the lack-of-fit test proposed by Su and Wei (1990) for the correlated data; examine their methods for cases with ordinal categorical data; and study linear regression diagnostic methods with censored data. 3) Analysis of repeated order categorical response data. We will study the mixed effects model under such a data structure.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA056844-02
Application #
3201259
Study Section
Special Emphasis Panel (SSS)
Project Start
1991-08-15
Project End
1994-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Chuang, S K; Tian, L; Wei, L J et al. (2002) Predicting dental implant survival by use of the marginal approach of the semi-parametric survival methods for clustered observations. J Dent Res 81:851-5
Chuang, S K; Wei, L J; Douglass, C W et al. (2002) Risk factors for dental implant failure: a strategy for the analysis of clustered failure-time observations. J Dent Res 81:572-7
Gilbert, Peter B; Wei, L J; Kosorok, Michael R et al. (2002) Simultaneous inferences on the contrast of two hazard functions with censored observations. Biometrics 58:773-80
Chuang, S K; Tian, L; Wei, L J et al. (2001) Kaplan-Meier analysis of dental implant survival: a strategy for estimating survival with clustered observations. J Dent Res 80:2016-20
Xu, X; Palmer, L J; Horvath, S et al. (2001) Combining multiple phenotypic traits optimally for detecting linkage with sib-pair observations. Genet Epidemiol 21 Suppl 1:S479-83
Cheng, S C; Fine, J P; Wei, L J (1998) Prediction of cumulative incidence function under the proportional hazards model. Biometrics 54:219-28
Betensky, R A (1997) Conditional power calculations for early acceptance of H0 embedded in sequential tests. Stat Med 16:465-77
Betensky, R A (1997) Early stopping to accept H(o) based on conditional power: approximations and comparisons. Biometrics 53:794-806
Zackin, R; Wei, L J (1997) Analysis of repeated virological measurements based on cell dilution assays. Stat Med 16:571-82
Yao, Q; Wei, L J (1996) Play the winner for phase II/III clinical trials. Stat Med 15:2413-23;discussion 2455-8

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