author's abstract). This five-year cancer control project, """"""""Companeros en la Salud,"""""""" features a church-based intervention to promote changes in the areas of diet and women's cancer prevention, that would reduce the risk of cancer among Hispanic women. Centered at the Graduate School of Public Health at San Diego State University and using churches as the unit of analysis, the project entails 12 matched pairs of churches randomized into an experimental and a control group. The investigators hypothesize that the experimental group intervention, a 13-week program led by community women, """"""""consejeras"""""""", will affect healthy behavior changes in those churches relative to those in the control group as indicated by (1) a lower consumption of dietary fat, (2) a higher consumption of dietary fiber, (3) a greater frequency of breast self-examination, and (4) a greater proportion of women (a) seeking clinical breast examinations, (b) obtaining mammograms, and (c) obtaining Papanicolaou examinations. A set of secondary analyses will focus on behavior changes at the individual level in order to test a """"""""biphasic curve"""""""" hypothesis in which acculturation is related to health status and behavior change among Hispanics. The investigators in this project also seek to identify predictors of compliance and relapse in behavior change efforts that reduce cancer risk among Hispanic women. Additionally, in a binational effort, they will examine patterns of change in a subsample of Hispanic women in Tijuana, Mexico to provide further understanding of the role of cultural, familial, and individual factors as facilitators (or inhibitors) of changes in behavior that are consistent with cancer risk reduction.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
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Special Emphasis Panel (SSS)
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Arizona State University-Tempe Campus
Schools of Arts and Sciences
United States
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Lopez, Vera A; Castro, Felipe G (2006) Participation and program outcomes in a church-based cancer prevention program for Hispanic women. J Community Health 31:343-62
Yang, J M; Yang, G Y; Medina, D J et al. (1999) Treatment of multidrug resistant (MDR1) murine leukemia with P-glycoprotein substrates accelerates the course of the disease. Biochem Biophys Res Commun 266:167-73
Castro, F G; Gutierres, S (1997) Drug and alcohol use among rural Mexican-Americans. NIDA Res Monogr 168:498-530
Yang, J M; Sullivan, G F; Hait, W N (1997) Regulation of the function of P-glycoprotein by epidermal growth factor through phospholipase C. Biochem Pharmacol 53:1597-604
Yang, J M; Sullivan, G F; Makhey, D B et al. (1997) Inhibitory effect of alkylating modulators on the function of P-glycoprotein. Oncol Res 9:477-84
Yang, J M; Chin, K V; Hait, W N (1996) Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells. Cancer Res 56:3490-4
Kaplan, R M; Navarro, A M; Castro, F G et al. (1996) Increased use of mammography among Hispanic women: baseline results from the NCI Cooperative Group on Cancer Prevention in Hispanic Communities. Am J Prev Med 12:467-71
Harmon, M P; Castro, F G; Coe, K (1996) Acculturation and cervical cancer: knowledge, beliefs, and behaviors of Hispanic women. Women Health 24:37-57
Balcazar, H; Castro, F G; Krull, J L (1995) Cancer risk reduction in Mexican American women: the role of acculturation, education, and health risk factors. Health Educ Q 22:61-84
Castro, F G; Elder, J; Coe, K et al. (1995) Mobilizing churches for health promotion in Latino communities: Companeros en la Salud. J Natl Cancer Inst Monogr :127-35

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