Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA057400-02S1
Application #
3201743
Study Section
Medical Biochemistry Study Section (MEDB)
Project Start
1992-08-01
Project End
1995-07-31
Budget Start
1993-08-01
Budget End
1994-07-31
Support Year
2
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Kester, Mark; Kolesnick, Richard (2003) Sphingolipids as therapeutics. Pharmacol Res 47:365-71
Kolesnick, R N; Kronke, M (1998) Regulation of ceramide production and apoptosis. Annu Rev Physiol 60:643-65
Haimovitz-Friedman, A; Kolesnick, R N; Fuks, Z (1997) Ceramide signaling in apoptosis. Br Med Bull 53:539-53
Haimovitz-Friedman, A; Kolesnick, R N; Fuks, Z (1997) Differential inhibition of radiation-induced apoptosis. Stem Cells 15 Suppl 2:43-7
Santana, P; Pena, L A; Haimovitz-Friedman, A et al. (1996) Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 86:189-99
Bose, R; Verheij, M; Haimovitz-Friedman, A et al. (1995) Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82:405-14
Kolesnick, R; Fuks, Z (1995) Ceramide: a signal for apoptosis or mitogenesis? J Exp Med 181:1949-52
Wright, S D; Kolesnick, R N (1995) Does endotoxin stimulate cells by mimicking ceramide? Immunol Today 16:297-302
Joseph, C K; Wright, S D; Bornmann, W G et al. (1994) Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells. J Biol Chem 269:17606-10
Jarvis, W D; Fornari Jr, F A; Browning, J L et al. (1994) Attenuation of ceramide-induced apoptosis by diglyceride in human myeloid leukemia cells. J Biol Chem 269:31685-92

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