Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA057690-03
Application #
2098417
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1994-07-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Lin, C M; Abcouwer, S F; Souba, W W (1999) Effect of dietary glutamate on chemotherapy-induced immunosuppression. Nutrition 15:687-96
Fischer, C P; Bode, B P; Souba, W W (1998) Adaptive alterations in cellular metabolism with malignant transformation. Ann Surg 227:627-34;discussion 634-6
Elgadi, K M; Labow, B I; Abcouwer, S F et al. (1998) Sepsis increases lung glutamine synthetase expression in the tumor-bearing host. J Surg Res 78:18-22
Easson, A M; Bode, B P; Fischer, C P et al. (1998) Effects of endotoxin challenge on hepatic amino acid transport during cancer. J Surg Res 77:29-34
Fischer, C P; Bode, B P; Hurley, B P et al. (1997) Alterations in oxidative metabolism and glutamine transport support glucose production in the tumor-influenced hepatocyte. J Surg Res 69:379-84
Elgadi, K M; Souba, W W; Bode, B P et al. (1997) Hepatic glutaminase gene expression in the tumor-bearing rat. J Surg Res 69:33-9
Wasa, M; Bode, B P; Souba, W W (1996) Adaptive regulation of amino acid transport in nutrient-deprived human hepatomas. Am J Surg 171:163-9
Espat, N J; Watkins, K T; Lind, D S et al. (1996) Dietary modulation of amino acid transport in rat and human liver. J Surg Res 63:263-8
Wasa, M; Bode, B P; Abcouwer, S F et al. (1996) Glutamine as a regulator of DNA and protein biosynthesis in human solid tumor cell lines. Ann Surg 224:189-97
Fischer, C P; Bode, B P; Souba, W W (1996) A sarcoma-derived protein regulates hepatocyte metabolism via autocrine production of tumor necrosis factor-alpha. Ann Surg 224:476-83;discussion 483-5

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