Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
7R01CA057856-05
Application #
2098596
Study Section
AIDS and Related Research Study Section 4 (ARRD)
Project Start
1992-08-07
Project End
1998-05-31
Budget Start
1996-09-23
Budget End
1998-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Carbone, David P; Ciernik, I Frank; Kelley, Michael J et al. (2005) Immunization with mutant p53- and K-ras-derived peptides in cancer patients: immune response and clinical outcome. J Clin Oncol 23:5099-107
Ciernik, I F; Berzofsky, J A; Carbone, D P (1996) Human lung cancer cells endogenously expressing mutant p53 process and present the mutant epitope and are lysed by mutant-specific cytotoxic T lymphocytes. Clin Cancer Res 2:877-82
Gabrilovich, D I; Ciernik, I F; Carbone, D P (1996) Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts. Cell Immunol 170:101-10
Lee, C T; Ciernik, I F; Wu, S et al. (1996) Increased immunogenicity of tumors bearing mutant p53 and P1A epitopes after transduction of B7-1 via recombinant adenovirus. Cancer Gene Ther 3:238-44
Ciernik, I F; Krayenbuhl, B H; Carbone, D P (1996) Puncture-mediated gene transfer to the skin. Hum Gene Ther 7:893-9
Ciernik, I F; Berzofsky, J; Carbone, D P (1995) Mutant oncopeptide immunization induces CTL specifically lysing tumor cells endogenously expressing the corresponding intact mutant p53. Hybridoma 14:139-42
Tang, D C; Johnston, S A; Carbone, D P (1994) Butyrate-inducible and tumor-restricted gene expression by adenovirus vectors. Cancer Gene Ther 1:15-20
Wiedenfeld, E A; Fernandez-Vina, M; Berzofsky, J A et al. (1994) Evidence for selection against human lung cancers bearing p53 missense mutations which occur within the HLA A*0201 peptide consensus motif. Cancer Res 54:1175-7
Tang, D C; Carbone, D P (1993) Potential application of gene therapy to lung cancer. Semin Oncol 20:368-73
Winter, S F; Sekido, Y; Minna, J D et al. (1993) Antibodies against autologous tumor cell proteins in patients with small-cell lung cancer: association with improved survival. J Natl Cancer Inst 85:2012-8

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