Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058022-05
Application #
2098735
Study Section
Special Emphasis Panel (SRC (68))
Project Start
1992-08-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Georgetown University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
049515844
City
Washington
State
DC
Country
United States
Zip Code
20057

  Publications

Zhu, Yuelin; Singh, Baljit; Hewitt, Stephen et al. (2006) Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays. Int J Oncol 28:67-76
Riggins, Rebecca B; Zwart, Alan; Nehra, Ruchi et al. (2005) The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells. Mol Cancer Ther 4:33-41
Bouker, Kerrie B; Skaar, Todd C; Riggins, Rebecca B et al. (2005) Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis 26:1527-35
Bouker, Kerrie B; Skaar, Todd C; Fernandez, David R et al. (2004) interferon regulatory factor-1 mediates the proapoptotic but not cell cycle arrest effects of the steroidal antiestrogen ICI 182,780 (faslodex, fulvestrant). Cancer Res 64:4030-9
Clarke, Robert; Liu, Minetta C; Bouker, Kerrie B et al. (2003) Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene 22:7316-39
Ellis, Matthew; Davis, Natalie; Coop, Andrew et al. (2002) Development and validation of a method for using breast core needle biopsies for gene expression microarray analyses. Clin Cancer Res 8:1155-66
Gu, Zhiping; Lee, Richard Y; Skaar, Todd C et al. (2002) Association of interferon regulatory factor-1, nucleophosmin, nuclear factor-kappaB, and cyclic AMP response element binding with acquired resistance to Faslodex (ICI 182,780). Cancer Res 62:3428-37
Wang, Yue; Lu, Jianping; Lee, Richard et al. (2002) Iterative normalization of cDNA microarray data. IEEE Trans Inf Technol Biomed 6:29-37
Clarke, R; Leonessa, F; Welch, J N et al. (2001) Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev 53:25-71
Clarke, R; Skaar, T C; Bouker, K B et al. (2001) Molecular and pharmacological aspects of antiestrogen resistance. J Steroid Biochem Mol Biol 76:71-84

Showing the most recent 10 out of 30 publications