Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058166-03
Application #
2098850
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1993-07-01
Project End
1997-06-30
Budget Start
1995-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Vana, Marcy L; Chen, Aiping; Boross, Peter et al. (2005) Mutations affecting cleavage at the p10-capsid protease cleavage site block Rous sarcoma virus replication. Retrovirology 2:58
Ridky, T W; Kikonyogo, A; Leis, J et al. (1998) Drug-resistant HIV-1 proteases identify enzyme residues important for substrate selection and catalytic rate. Biochemistry 37:13835-45
Wu, J; Adomat, J M; Ridky, T W et al. (1998) Structural basis for specificity of retroviral proteases. Biochemistry 37:4518-26
Weber, I T; Harrison, R W (1997) Molecular mechanics calculations on Rous sarcoma virus protease with peptide substrates. Protein Sci 6:2365-74
Tozser, J; Yin, F H; Cheng, Y S et al. (1997) Activity of tethered human immunodeficiency virus 1 protease containing mutations in the flap region of one subunit. Eur J Biochem 244:235-41
Tozser, J; Bagossi, P; Weber, I T et al. (1997) Studies on the symmetry and sequence context dependence of the HIV-1 proteinase specificity. J Biol Chem 272:16807-14
Weber, I T; Wu, J; Adomat, J et al. (1997) Crystallographic analysis of human immunodeficiency virus 1 protease with an analog of the conserved CA-p2 substrate -- interactions with frequently occurring glutamic acid residue at P2' position of substrates. Eur J Biochem 249:523-30
Ridky, T W; Cameron, C E; Cameron, J et al. (1996) Human immunodeficiency virus, type 1 protease substrate specificity is limited by interactions between substrate amino acids bound in adjacent enzyme subsites. J Biol Chem 271:4709-17
Ridky, T W; Bizub-Bender, D; Cameron, C E et al. (1996) Programming the Rous sarcoma virus protease to cleave new substrate sequences. J Biol Chem 271:10538-44
Tozser, J; Bagossi, P; Weber, I T et al. (1996) Comparative studies on the substrate specificity of avian myeloblastosis virus proteinase and lentiviral proteinases. J Biol Chem 271:6781-8

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