Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA058292-04
Application #
2098987
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-04-01
Project End
2001-01-31
Budget Start
1996-04-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Si, Jutong; Collins, Steven J (2002) IL-3-induced enhancement of retinoic acid receptor activity is mediated through Stat5, which physically associates with retinoic acid receptors in an IL-3-dependent manner. Blood 100:4401-9
Johnson, Barton S; Mueller, LeMoyne; Si, Jutong et al. (2002) The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood 99:746-53
Collins, S J; Ulmer, J; Purton, L E et al. (2001) Multipotent hematopoietic cell lines derived from C/EBPalpha(-/-) knockout mice display granulocyte macrophage-colony-stimulating factor, granulocyte- colony-stimulating factor, and retinoic acid-induced granulocytic differentiation. Blood 98:2382-8
Purton, L E; Morris, J C; Bernstein, I D et al. (2001) All-trans retinoic acid facilitates oncoretrovirus-mediated transduction of hematopoietic repopulating stem cells. J Hematother Stem Cell Res 10:815-25
Purton, L E; Bernstein, I D; Collins, S J (2000) All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells. Blood 95:470-7
Purton, L E; Bernstein, I D; Collins, S J (1999) All-trans retinoic acid delays the differentiation of primitive hematopoietic precursors (lin-c-kit+Sca-1(+)) while enhancing the terminal maturation of committed granulocyte/monocyte progenitors. Blood 94:483-95
Johnson, B S; Chandraratna, R A; Heyman, R A et al. (1999) Retinoid X receptor (RXR) agonist-induced activation of dominant-negative RXR-retinoic acid receptor alpha403 heterodimers is developmentally regulated during myeloid differentiation. Mol Cell Biol 19:3372-82
Filippova, G N; Lindblom, A; Meincke, L J et al. (1998) A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers. Genes Chromosomes Cancer 22:26-36
Scott, L M; Mueller, L; Collins, S J (1996) E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. Blood 88:2517-30
Tsai, S; Bartelmez, S; Sitnicka, E et al. (1994) Lymphohematopoietic progenitors immortalized by a retroviral vector harboring a dominant-negative retinoic acid receptor can recapitulate lymphoid, myeloid, and erythroid development. Genes Dev 8:2831-41

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