Abstract

Breast cancer represents a significant health care issue in the United States. Screening with mammography and physical examination have resulted in a decreased mortality from breast cancer due to earlier detection. A major problem with these screening modalities is their nonspecificity. The 70-85% benign surgical breast biopsy rate subjects a large number of women to unnecessary surgery and places a significant financial burden on the health care system. The object of this proposal is to investigate the high resolution MR imaging characteristics of suspicious breast lesions. The interdisciplinary consists of three radiologists, a pathologist, and a breast surgeon. We plan to obtain high-resolution MR images of only the suspicious portion of the breast as identified by mammography or physical exam. Lesions will be characterized by morphologic, signal intensity, and enhancement patterns. The proposal also includes a detailed correlation between pathology and images of resected specimens. With the aid of statistical consultant we will assess the accuracy of high- resolution MR imaging to identify specific pathologic entities. We also plan to identify those patients in which high-resolution MR imaging may offer an alternative to surgical biopsy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058358-02
Application #
2099066
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1993-02-01
Project End
1996-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Nunes, Linda White; Englander, Sarah A; Charafeddine, Riad et al. (2002) Optimal post-contrast timing of breast MR image acquisition for architectural feature analysis. J Magn Reson Imaging 16:42-50
Katz-Brull, Rachel; Lavin, Philip T; Lenkinski, Robert E (2002) Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. J Natl Cancer Inst 94:1197-203
Nunes, L W; Schnall, M D; Orel, S G (2001) Update of breast MR imaging architectural interpretation model. Radiology 219:484-94
Cecil, K M; Schnall, M D; Siegelman, E S et al. (2001) The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy. Breast Cancer Res Treat 68:45-54
Nunes, L W (2001) Architectural-based interpretations of breast MR imaging. Magn Reson Imaging Clin N Am 9:303-20, vi
Schnall, M D; Rosten, S; Englander, S et al. (2001) A combined architectural and kinetic interpretation model for breast MR images. Acad Radiol 8:591-7
Hrung, J M; Langlotz, C P; Orel, S G et al. (1999) Cost-effectiveness of MR imaging and core-needle biopsy in the preoperative work-up of suspicious breast lesions. Radiology 213:39-49
Nunes, L W; Schnall, M D; Orel, S G et al. (1999) Correlation of lesion appearance and histologic findings for the nodes of a breast MR imaging interpretation model. Radiographics 19:79-92
Hrung, J M; Sonnad, S S; Schwartz, J S et al. (1999) Accuracy of MR imaging in the work-up of suspicious breast lesions: a diagnostic meta-analysis. Acad Radiol 6:387-97
Rovno, H D; Siegelman, E S; Reynolds, C et al. (1999) Solitary intraductal papilloma: findings at MR imaging and MR galactography. AJR Am J Roentgenol 172:151-5

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