Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058462-03
Application #
2099148
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1993-01-01
Project End
1997-12-31
Budget Start
1995-01-01
Budget End
1997-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Ohio State University
Department
Type
Schools of Pharmacy
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Brueggemeier, R W; Gilbert, N E; Gu, X et al. (1997) Aromatase inhibition in JAr choriocarcinoma cells by 7alpha-arylaliphatic androgens. J Steroid Biochem Mol Biol 61:73-7
Burak Jr, W E; Quinn, A L; Farrar, W B et al. (1997) Androgens influence estrogen-induced responses in human breast carcinoma cells through cytochrome P450 aromatase. Breast Cancer Res Treat 44:57-64
O'Reilly, J M; Brueggemeier, R W (1996) 7alpha-Arylaliphatic androsta-1,4-diene-3,17-diones as enzyme-activated irreversible inhibitors of aromatase. J Steroid Biochem Mol Biol 59:93-102
O'Reilly, J M; Li, N; Duax, W L et al. (1995) Synthesis, structure elucidation, and biochemical evaluation of 7 alpha- and 7 beta-arylaliphatic-substituted androst-4-ene-3,17-diones as inhibitors of aromatase. J Med Chem 38:2842-50