Improved Cancer Therapy Via Molecular Studies of the Pgp - Gene Scarborough

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Cancer Institute (NCI)
Type: Research Project (R01)
Project #: 5R01CA058491-03
Application #: 2099170
Study Section: Experimental Therapeutics Subcommittee 1 (ET)

Project Start: 1993-01-01
Project End: 1996-12-31
Budget Start: 1995-01-01
Budget End: 1996-12-31
Support Year: 3
Fiscal Year: 1995
Total Cost
Indirect Cost

Institution

Name: University of North Carolina Chapel Hill
Department: Pharmacology
Type: Schools of Medicine
DUNS #: 078861598

City: Chapel Hill
State: NC
Country: United States
Zip Code: 27599

Related projects


NIH 1995 R01 CA	Improved Cancer Therapy Via Molecular Studies of the Pgp Scarborough, Gene A. / University of North Carolina Chapel Hill
NIH 1994 R01 CA	Improved Cancer Therapy Via Molecular Studies of the Pgp Scarborough, Gene A. / University of North Carolina Chapel Hill
NIH 1993 R01 CA	Improved Cancer Therapy Via Molecular Studies of the Pgp Scarborough, Gene A. / University of North Carolina Chapel Hill

Publications

Mao, Q; Scarborough, G A (1997) Purification of functional human P-glycoprotein expressed in Saccharomyces cerevisiae. Biochim Biophys Acta 1327:107-18

Rao, U S (1995) Mutation of glycine 185 to valine alters the ATPase function of the human P-glycoprotein expressed in Sf9 cells. J Biol Chem 270:6686-90

Rao, U S; Fine, R L; Scarborough, G A (1994) Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol 48:287-92

Rao, U S; Scarborough, G A (1994) Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein. Mol Pharmacol 45:773-6

Comments

Be the first to comment on Gene Scarborough's grant