Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058607-04
Application #
2099288
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1993-08-01
Project End
1998-05-31
Budget Start
1996-06-15
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cold Spring Harbor Laboratory
Department
Type
DUNS #
065968786
City
Cold Spring Harbor
State
NY
Country
United States
Zip Code
11724
Helfman, D M; Levy, E T; Berthier, C et al. (1999) Caldesmon inhibits nonmuscle cell contractility and interferes with the formation of focal adhesions. Mol Biol Cell 10:3097-112
Helfman, D M; Berthier, C; Grossman, J et al. (1999) Nonmuscle tropomyosin-4 requires coexpression with other low molecular weight isoforms for binding to thin filaments in cardiomyocytes. J Cell Sci 112 ( Pt 3):371-80
Temm-Grove, C J; Jockusch, B M; Weinberger, R P et al. (1998) Distinct localizations of tropomyosin isoforms in LLC-PK1 epithelial cells suggests specialized function at cell-cell adhesions. Cell Motil Cytoskeleton 40:393-407
Gimona, M; Lando, Z; Dolginov, Y et al. (1997) Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins. J Cell Sci 110 ( Pt 5):611-21
Watakabe, A; Kobayashi, R; Helfman, D M (1996) N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. J Cell Sci 109 ( Pt 9):2299-310
Gimona, M; Kazzaz, J A; Helfman, D M (1996) Forced expression of tropomyosin 2 or 3 in v-Ki-ras-transformed fibroblasts results in distinct phenotypic effects. Proc Natl Acad Sci U S A 93:9618-23
Temm-Grove, C J; Guo, W; Helfman, D M (1996) Low molecular weight rat fibroblast tropomyosin 5 (TM-5): cDNA cloning, actin-binding, localization, and coiled-coil interactions. Cell Motil Cytoskeleton 33:223-40
Pittenger, M F; Kistler, A; Helfman, D M (1995) Alternatively spliced exons of the beta tropomyosin gene exhibit different affinities for F-actin and effects with nonmuscle caldesmon. J Cell Sci 108 ( Pt 10):3253-65
Gimona, M; Watakabe, A; Helfman, D M (1995) Specificity of dimer formation in tropomyosins: influence of alternatively spliced exons on homodimer and heterodimer assembly. Proc Natl Acad Sci U S A 92:9776-80
Helfman, D M (1994) The generation of protein isoform diversity by alternative RNA splicing. Soc Gen Physiol Ser 49:105-15

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