Molecular Analysis of the ALPHA-6 BETA-4 Integrin

Giancotti, Filippo G.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA058976-03
• Application #: 2099586
• Study Section: Pathobiochemistry Study Section (PBC)
• Project Start: 1994-01-01
• Project End: 1996-09-30
• Budget Start: 1996-01-01
• Budget End: 1996-09-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: New York University
• Department: Pathology
• Type: Schools of Medicine
• City: New York
• State: NY
• Country: United States
• Zip Code: 10016

Publications

Okada, Tomoyo; Sinha, Surajit; Esposito, Ilaria et al. (2015) The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling. Nat Cell Biol 17:81-94

Dans, M; Gagnoux-Palacios, L; Blaikie, P et al. (2001) Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem 276:1494-502

Mariotti, A; Kedeshian, P A; Dans, M et al. (2001) EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol 155:447-58

Murgia, C; Blaikie, P; Kim, N et al. (1998) Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J 17:3940-51

Munger, J S; Harpel, J G; Giancotti, F G et al. (1998) Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1. Mol Biol Cell 9:2627-38

Wary, K K; Mariotti, A; Zurzolo, C et al. (1998) A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Cell 94:625-34

Mainiero, F; Murgia, C; Wary, K K et al. (1997) The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation. EMBO J 16:2365-75

Mainiero, F; Pepe, A; Yeon, M et al. (1996) The intracellular functions of alpha6beta4 integrin are regulated by EGF. J Cell Biol 134:241-53

Wary, K K; Mainiero, F; Isakoff, S J et al. (1996) The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 87:733-43

Mainiero, F; Pepe, A; Wary, K K et al. (1995) Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J 14:4470-81