Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA059692-03
Application #
2100265
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1994-05-01
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Yebra, M; Goretzki, L; Pfeifer, M et al. (1999) Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction. Exp Cell Res 250:231-40
Mueller, B M; Ruf, W (1998) Requirement for binding of catalytically active factor VIIa in tissue factor-dependent experimental metastasis. J Clin Invest 101:1372-8
Ott, I; Fischer, E G; Miyagi, Y et al. (1998) A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280. J Cell Biol 140:1241-53
Goretzki, L; Mueller, B M (1998) Low-density-lipoprotein-receptor-related protein (LRP) interacts with a GTP-binding protein. Biochem J 336 ( Pt 2):381-6
DeClerck, Y A; Imren, S; Montgomery, A M et al. (1997) Proteases and protease inhibitors in tumor progression. Adv Exp Med Biol 425:89-97
Goretzki, L; Mueller, B M (1997) Receptor-mediated endocytosis of urokinase-type plasminogen activator is regulated by cAMP-dependent protein kinase. J Cell Sci 110 ( Pt 12):1395-402
Stahl, A; Mueller, B M (1997) Melanoma cell migration on vitronectin: regulation by components of the plasminogen activation system. Int J Cancer 71:116-22
Ruf, W; Mueller, B M (1996) Tissue factor in cancer angiogenesis and metastasis. Curr Opin Hematol 3:379-84
Stahl, A; Mueller, B M (1995) The urokinase-type plasminogen activator receptor, a GPI-linked protein, is localized in caveolae. J Cell Biol 129:335-44
Mueller, B M; Yu, Y B; Laug, W E (1995) Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice. Proc Natl Acad Sci U S A 92:205-9

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