Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060087-02
Application #
2100710
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-01-04
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Shen, Quiang; Singh, Pomila (2004) Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. Oncogene 23:2454-64
Rengifo-Cam, William; Singh, Pomila (2004) Role of progastrins and gastrins and their receptors in GI and pancreatic cancers: targets for treatment. Curr Pharm Des 10:2345-58
Singh, P; Cobb, S; Rengifo-Cam, W et al. (2004) Locomotor activity and behavior of mutant mice deleted for gastrin gene expression. J Physiol Pharmacol 55:269-78
Singh, P; Lu, X; Cobb, S et al. (2003) Progastrin1-80 stimulates growth of intestinal epithelial cells in vitro via high-affinity binding sites. Am J Physiol Gastrointest Liver Physiol 284:G328-39
Brown, D; Yallampalli, U; Owlia, A et al. (2003) pp60c-Src Kinase mediates growth effects of the full-length precursor progastrin1-80 peptide on rat intestinal epithelial cells, in vitro. Endocrinology 144:201-11
Cobb, Stephanie; Wood, Thomas; Tessarollo, Lino et al. (2002) Deletion of functional gastrin gene markedly increases colon carcinogenesis in response to azoxymethane in mice. Gastroenterology 123:516-30
Dai, B; Wu, H; Holthuizen, E et al. (2001) Identification of a novel cis element required for cell density-dependent down-regulation of insulin-like growth factor-2 P3 promoter activity in Caco2 cells. J Biol Chem 276:6937-44
Wu, H; Rao, G N; Dai, B et al. (2000) Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3. J Biol Chem 275:32491-8
Singh, P; Velasco, M; Given, R et al. (2000) Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 119:162-71
Singh, P; Dai, B; Given, R L et al. (1998) Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation. Gastroenterology 114:1221-9

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