Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060331-03
Application #
2101044
Study Section
Radiation Study Section (RAD)
Project Start
1994-02-01
Project End
1999-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
William Beaumont Hospital
Department
Type
DUNS #
City
Royal Oak
State
MI
Country
United States
Zip Code
48073
VanderWaal, R P; Griffith, C L; Wright, W D et al. (2001) Delaying S-phase progression rescues cells from heat-induced S-phase hypertoxicity. J Cell Physiol 187:236-43
Sekhar, K R; Soltaninassab, S R; Borrelli, M J et al. (2000) Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase. Biochem Biophys Res Commun 270:311-7
Freeman, M L; Borrelli, M J; Meredith, M J et al. (1999) On the path to the heat shock response: destabilization and formation of partially folded protein intermediates, a consequence of protein thiol modification. Free Radic Biol Med 26:737-45
Borrelli, M J; Stafford, D M; Rausch, C M et al. (1998) Diamide-induced cytotoxicity and thermotolerance in CHO cells. J Cell Physiol 177:483-92
McDuffee, A T; Senisterra, G; Huntley, S et al. (1997) Proteins containing non-native disulfide bonds generated by oxidative stress can act as signals for the induction of the heat shock response. J Cell Physiol 171:143-51
Borrelli, M J; Lepock, J R; Frey, H E et al. (1996) Excess protein in nuclei isolated from heat-shocked cells results from a reduced extractability of nuclear proteins. J Cell Physiol 167:369-79
Borrelli, M J; Stafford, D M; Karczewski, L A et al. (1996) Thermotolerance expression in mitotic CHO cells without increased translation of heat shock proteins. J Cell Physiol 169:420-8
Freeman, M L; Borrelli, M J; Syed, K et al. (1995) Characterization of a signal generated by oxidation of protein thiols that activates the heat shock transcription factor. J Cell Physiol 164:356-66