Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA060548-04
Application #
2101301
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1996-08-09
Project End
2000-05-31
Budget Start
1996-08-09
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Purdue University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Ambrose, Andrew J; Santos, Evelyne A; Jimenez, Paula C et al. (2017) Ritterostatin GN 1N , a Cephalostatin-Ritterazine Bis-steroidal Pyrazine Hybrid, Selectively Targets GRP78. Chembiochem 18:506-510
Kanduluru, Ananda Kumar; Banerjee, Prabal; Beutler, John A et al. (2013) A convergent total synthesis of the potent cephalostatin/ritterazine hybrid -25-epi ritterostatin GN1N. J Org Chem 78:9085-92
Kumar, Kanduluru Ananda; La Clair, James J; Fuchs, Philip L (2011) Synthesis and evaluation of a fluorescent ritterazine-cephalostatin hybrid. Org Lett 13:5334-7
Lee, Seongmin; LaCour, Thomas G; Fuchs, Philip L (2009) Chemistry of trisdecacyclic pyrazine antineoplastics: the cephalostatins and ritterazines. Chem Rev 109:2275-314
Lee, Seongmin; Jamieson, Daniel; Fuchs, Philip L (2009) Synthesis of C14,15-dihydro-C22,25-epi north unit of cephalostatin 1 via ""red-ox"" modifications of hecogenin acetate. Org Lett 11:5-8
Lee, Jong Seok; Cao, Hui; Fuchs, Philip L (2007) Ruthenium-catalyzed mild C-H oxyfunctionalization of cyclic steroidal ethers. J Org Chem 72:5820-3
Lee, Jong Seok; Fuchs, Philip L (2005) A biomimetically inspired, efficient synthesis of the South 7 hemisphere of cephalostatin 7. J Am Chem Soc 127:13122-3
Lee, Seongmin; Fuchs, Philip L (2004) An efficient C-H oxidation protocol for alpha-hydroxylation of cyclic steroidal ethers. Org Lett 6:1437-40
Li, Wei; Fuchs, Philip L (2003) Polyphosphoric acid trimethylsilyl ester promoted intramolecular acylation of an olefin by a carboxylic acid: convenient construction of C-18-functionalized delta14-hecogenin acetate. Org Lett 5:4061-4
Lee, Jong Seok; Fuchs, Philip L (2003) New oxidative tools for the functionalization of the cephalostatin north 1 hemisphere. Org Lett 5:2247-50

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