DNA Modification in Carcinogenesis and Mutation

Bestor, Timothy H.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Research Project (R01)
• Project #: 5R01CA060610-04
• Application #: 2101355
• Study Section: Chemical Pathology Study Section (CPA)
• Project Start: 1993-07-15
• Project End: 1997-10-31
• Budget Start: 1996-05-01
• Budget End: 1997-10-31
• Support Year: 4
• Fiscal Year: 1996

Institution

• Name: Columbia University (N.Y.)
• Department: Genetics
• Type: Schools of Medicine
• DUNS #: 167204994
• City: New York
• State: NY
• Country: United States
• Zip Code: 10032

Publications

Mertineit, C; Yoder, J A; Taketo, T et al. (1998) Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development 125:889-97

Bestor, T H (1998) The host defence function of genomic methylation patterns. Novartis Found Symp 214:187-95;discussion 195-9, 228-32

Yoder, J A; Bestor, T H (1998) A candidate mammalian DNA methyltransferase related to pmt1p of fission yeast. Hum Mol Genet 7:279-84

Tycko, B; Trasler, J; Bestor, T (1997) Genomic imprinting: gametic mechanisms and somatic consequences. J Androl 18:480-6

Trasler, J M; Trasler, D G; Bestor, T H et al. (1996) DNA methyltransferase in normal and Dnmtn/Dnmtn mouse embryos. Dev Dyn 206:239-47

Yoder, J A; Bestor, T H (1996) Genetic analysis of genomic methylation patterns in plants and mammals. Biol Chem 377:605-10

Bestor, T H; Tycko, B (1996) Creation of genomic methylation patterns. Nat Genet 12:363-7

Yoder, J A; Yen, R W; Vertino, P M et al. (1996) New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J Biol Chem 271:31092-7

Nelson, H C; Bestor, T H (1996) Base eversion and shuffling by DNA methyltransferases. Chem Biol 3:419-23

Jue, K; Bestor, T H; Trasler, J M (1995) Regulated synthesis and localization of DNA methyltransferase during spermatogenesis. Biol Reprod 53:561-9