Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA060662-03
Application #
2101410
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-05-16
Project End
1998-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Peiper, Matthias; Goedegebuure, Peter S; Alldinger, Ingo et al. (2002) Comparison of various sources of antigen-presenting cells for the generation of GP2-tumor peptide specific cytotoxic T-lymphocytes. Anticancer Res 22:3357-63
Bernstorff, Wolfram V; Glickman, Jonathan N; Odze, Robert D et al. (2002) Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors. Implications for immune privilege and immune escape. Cancer 94:2552-60
Joo, H G; Goedegebuure, P S; Sadanaga, N et al. (2001) Expression and function of galectin-3, a beta-galactoside-binding protein in activated T lymphocytes. J Leukoc Biol 69:555-64
Lockhart, D C; Chan, A K; Mak, S et al. (2001) Loss of T-cell receptor-CD3zeta and T-cell function in tumor-infiltrating lymphocytes but not in tumor-associated lymphocytes in ovarian carcinoma. Surgery 129:749-56
Chan, A K; Goedegebuure, P S; von Bernstorff, W et al. (2000) B7.1 costimulation increases T-cell proliferation and cytotoxicity via selective expansion of specific variable alpha and beta genes of the T-cell receptor. Surgery 127:342-50
Chan, A K; Lockhart, D C; von Bernstorff, W et al. (1999) Soluble MUC1 secreted by human epithelial cancer cells mediates immune suppression by blocking T-cell activation. Int J Cancer 82:721-6
Sadanaga, N; Nagoshi, M; Lederer, J A et al. (1999) Local secretion of IFN-gamma induces an antitumor response: comparison between T cells plus IL-2 and IFN-gamma transfected tumor cells. J Immunother 22:315-23
Nagoshi, M; Sadanaga, N; Joo, H G et al. (1999) Tumor-specific cytokine release by donor T cells induces an effective host anti-tumor response through recruitment of host naive antigen presenting cells. Int J Cancer 80:308-14
Burger, U L; Chang, M P; Nagoshi, M et al. (1996) Improved in vivo efficacy of tumor-infiltrating lymphocytes after restimulation with irradiated tumor cells in vitro. Ann Surg Oncol 3:580-7
Linehan, D C; Goedegebuure, P S; Eberlein, T J (1996) Vaccine therapy for cancer. Ann Surg Oncol 3:219-28