Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA060994-03S1
Application #
2101757
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1993-08-18
Project End
1996-06-30
Budget Start
1995-08-31
Budget End
1996-06-30
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Dermatology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Wang, Y; Rosenstein, B; Goldwyn, S et al. (1998) Differential regulation of P53 and Bcl-2 expression by ultraviolet A and B. J Invest Dermatol 111:380-4
Wang, Y; Zhang, X; Lebwohl, M et al. (1998) Inhibition of ultraviolet B (UVB)-induced c-fos and c-jun expression in vivo by a tyrosine kinase inhibitor genistein. Carcinogenesis 19:649-54
Brown, A; Jolly, P; Wei, H (1998) Genistein modulates neuroblastoma cell proliferation and differentiation through induction of apoptosis and regulation of tyrosine kinase activity and N-myc expression. Carcinogenesis 19:991-7
Wei, H; Bowen, R; Zhang, X et al. (1998) Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice. Carcinogenesis 19:1509-14
Wei, H; Ca, Q; Rahn, R et al. (1998) DNA structural integrity and base composition affect ultraviolet light-induced oxidative DNA damage. Biochemistry 37:6485-90
Wei, H; Cai, Q; Tian, L et al. (1998) Tamoxifen reduces endogenous and UV light-induced oxidative damage to DNA, lipid and protein in vitro and in vivo. Carcinogenesis 19:1013-8
Zhang, X; Rosenstein, B S; Wang, Y et al. (1997) Induction of 8-oxo-7,8-dihydro-2'-deoxyguanosine by ultraviolet radiation in calf thymus DNA and HeLa cells. Photochem Photobiol 65:119-24
Giles, D; Wei, H (1997) Effect of structurally related flavones/isoflavones on hydrogen peroxide production and oxidative DNA damage in phorbol ester-stimulated HL-60 cells. Nutr Cancer 29:77-82
Wei, H; Cai, Q; Rahn, R et al. (1997) Singlet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of 8-hydroxy-deoxyguanosine in DNA. Free Radic Biol Med 23:148-54
Zhang, X; Rosenstein, B S; Wang, Y et al. (1997) Identification of possible reactive oxygen species involved in ultraviolet radiation-induced oxidative DNA damage. Free Radic Biol Med 23:980-5

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