Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061033-03
Application #
2101805
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-06-15
Project End
1999-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Duke University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Advani, Anjali S; Dressman, Holly K; Quiroz, Marisol et al. (2004) Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. Leuk Res 28:285-94
Advani, Anjali S; Pendergast, Ann Marie (2002) Bcr-Abl variants: biological and clinical aspects. Leuk Res 26:713-20
Quackenbush, R C; Reuther, G W; Miller, J P et al. (2000) Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. Blood 95:2913-21
LaMontagne Jr, K R; Flint, A J; Franza Jr, B R et al. (1998) Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo. Mol Cell Biol 18:2965-75
Pear, W S; Miller, J P; Xu, L et al. (1998) Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood 92:3780-92
Dai, Z; Quackenbush, R C; Courtney, K D et al. (1998) Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway. Genes Dev 12:1415-24
Reuther, J Y; Reuther, G W; Cortez, D et al. (1998) A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. Genes Dev 12:968-81
Cortez, D; Reuther, G; Pendergast, A M (1997) The Bcr-Abl tyrosine kinase activates mitogenic signaling pathways and stimulates G1-to-S phase transition in hematopoietic cells. Oncogene 15:2333-42
Cortez, D; Stoica, G; Pierce, J H et al. (1996) The BCR-ABL tyrosine kinase inhibits apoptosis by activating a Ras-dependent signaling pathway. Oncogene 13:2589-94
Reuther, G W; Pendergast, A M (1996) The roles of 14-3-3 proteins in signal transduction. Vitam Horm 52:149-75

Showing the most recent 10 out of 15 publications