A population-based case-control study of epithelial ovarian cancer, which will investigate the association between genital talc use, infertility, infertility treatments, hormone use, oral contraceptive use, gynecologic operations, nutritional factors and physical activity and the development of epithelial ovarian cancer is proposed. The study will be performed in the multi-ethnic, multi-racial community of Cook County, Illinois. Approximately 750 incident epithelial ovarian cancer cases occurring in this community will be ascertained over a three year period. Histologic specimens obtained during diagnostic operation of the case will be evaluated by the study pathologist to consistently classify histologic subtype and degree of malignancy. Approximately 1500 population controls, matched on age and race, will be ascertained using random digit dialing (less than age 65) and lists of medicare recipients maintained by the Health Care Financing Administration (age 65 or higher). Etiologic information will be ascertained using a self-administered food-frequency questionnaire and an in-person interview. Analyses will be performed using conditional logistic regression and polychotomous logistic regression.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061093-02
Application #
2101854
Study Section
Special Emphasis Panel (SRC (52))
Project Start
1993-09-15
Project End
1998-06-30
Budget Start
1994-09-01
Budget End
1995-06-30
Support Year
2
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Illinois at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
121911077
City
Chicago
State
IL
Country
United States
Zip Code
60612
Kim, Seijeoung; Dolecek, Therese A; Davis, Faith G (2010) Racial differences in stage at diagnosis and survival from epithelial ovarian cancer: a fundamental cause of disease approach. Soc Sci Med 71:274-281
Modugno, Francesmary; Ness, Roberta B; Allen, Glenn O et al. (2004) Oral contraceptive use, reproductive history, and risk of epithelial ovarian cancer in women with and without endometriosis. Am J Obstet Gynecol 191:733-40
Ness, Roberta B; Cramer, Daniel W; Goodman, Marc T et al. (2002) Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies. Am J Epidemiol 155:217-24