Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061262-03
Application #
2102002
Study Section
Special Emphasis Panel (SRC (54))
Project Start
1993-12-15
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas
Department
Biochemistry
Type
Schools of Medicine
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160
Lee, Dae Kee; Geiser, Jim; Dufner-Beattie, Jodi et al. (2003) Pancreatic metallothionein-I may play a role in zinc homeostasis during maternal dietary zinc deficiency in mice. J Nutr 133:45-50
Andrews, G K; Lee, D K; Ravindra, R et al. (2001) The transcription factors MTF-1 and USF1 cooperate to regulate mouse metallothionein-I expression in response to the essential metal zinc in visceral endoderm cells during early development. EMBO J 20:1114-22
Andrews, G K (2001) Cellular zinc sensors: MTF-1 regulation of gene expression. Biometals 14:223-37
Langmade, S J; Ravindra, R; Daniels, P J et al. (2000) The transcription factor MTF-1 mediates metal regulation of the mouse ZnT1 gene. J Biol Chem 275:34803-9
Andrews, G K (2000) Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 59:95-104
Chu, W A; Moehlenkamp, J D; Bittel, D et al. (1999) Cadmium-mediated activation of the metal response element in human neuroblastoma cells lacking functional metal response element-binding transcription factor-1. J Biol Chem 274:5279-84
Andrews, G K; Geiser, J (1999) Expression of the mouse metallothionein-I and -II genes provides a reproductive advantage during maternal dietary zinc deficiency. J Nutr 129:1643-8
Li, Q; Hu, N; Daggett, M A et al. (1998) Participation of upstream stimulator factor (USF) in cadmium-induction of the mouse metallothionein-I gene. Nucleic Acids Res 26:5182-9
Dalton, T P; Bittel, D; Andrews, G K (1997) Reversible activation of mouse metal response element-binding transcription factor 1 DNA binding involves zinc interaction with the zinc finger domain. Mol Cell Biol 17:2781-9
Dalton, T P; Li, Q; Bittel, D et al. (1996) Oxidative stress activates metal-responsive transcription factor-1 binding activity. Occupancy in vivo of metal response elements in the metallothionein-I gene promoter. J Biol Chem 271:26233-41

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