Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061268-03
Application #
2102010
Study Section
Special Emphasis Panel (SRC (54))
Project Start
1994-02-01
Project End
1997-12-31
Budget Start
1996-04-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Quaife, C J; Cherne, R L; Newcomb, T G et al. (1999) Metallothionein overexpression suppresses hepatic hyperplasia induced by hepatitis B surface antigen. Toxicol Appl Pharmacol 155:107-16
Quaife, C J; Kelly, E J; Masters, B A et al. (1998) Ectopic expression of metallothionein-III causes pancreatic acinar cell necrosis in transgenic mice. Toxicol Appl Pharmacol 148:148-57
Erickson, J C; Hollopeter, G; Thomas, S A et al. (1997) Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J Neurosci 17:1271-81
Kelly, E J; Sandgren, E P; Brinster, R L et al. (1997) A pair of adjacent glucocorticoid response elements regulate expression of two mouse metallothionein genes. Proc Natl Acad Sci U S A 94:10045-50
Liu, Y P; Liu, J; Palmiter, R D et al. (1996) Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity. Toxicol Appl Pharmacol 137:307-15
Kelly, E J; Palmiter, R D (1996) A murine model of Menkes disease reveals a physiological function of metallothionein. Nat Genet 13:219-22
Kelly, E J; Quaife, C J; Froelick, G J et al. (1996) Metallothionein I and II protect against zinc deficiency and zinc toxicity in mice. J Nutr 126:1782-90
Quaife, C J; Veith, G C; Palmiter, R D (1996) Transformation of liver by SV-40 T-antigen in transgenic mice is unaffected by metallothionein. Cancer Lett 106:125-31
Palmiter, R D; Cole, T B; Findley, S D (1996) ZnT-2, a mammalian protein that confers resistance to zinc by facilitating vesicular sequestration. EMBO J 15:1784-91
Dalton, T; Fu, K; Palmiter, R D et al. (1996) Transgenic mice that overexpress metallothionein-I resist dietary zinc deficiency. J Nutr 126:825-33

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