Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA061299-03
Application #
2102035
Study Section
Special Emphasis Panel (SRC (54))
Project Start
1994-01-01
Project End
1997-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Pharmacology
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Woo, E S; Rice, R L; Lazo, J S (1999) Cell cycle dependent subcellular distribution of Cdc25B subtypes. Oncogene 18:2770-6
Kondo, Y; Yanagiya, T; Himeno, S et al. (1999) Simian virus 40-transformed metallothionein null cells showed increased sensitivity to cadmium but not to zinc, copper, mercury or nickel. Life Sci 64:PL145-50
Fabisiak, J P; Tyurin, V A; Tyurina, Y Y et al. (1999) Redox regulation of copper-metallothionein. Arch Biochem Biophys 363:171-81
Yang, Y Y; Robbins, P D; Lazo, J S (1998) Differential transactivation of human metallothionein-IIa in cisplatin-resistant and -sensitive cells. Oncol Res 10:85-98
Koldamova, R P; Lefterov, I M; Gadjeva, V G et al. (1998) Essential binding and functional domains of human bleomycin hydrolase. Biochemistry 37:2282-90
Fabisiak, J P; Kagan, V E; Tyurina, Y Y et al. (1998) Paraquat-induced phosphatidylserine oxidation and apoptosis are independent of activation of PLA2. Am J Physiol 274:L793-802
Fabisiak, J P; Tyurina, Y Y; Tyurin, V A et al. (1998) Random versus selective membrane phospholipid oxidation in apoptosis: role of phosphatidylserine. Biochemistry 37:13781-90
Woo, E S; Lazo, J S (1997) Nucleocytoplasmic functionality of metallothionein. Cancer Res 57:4236-41
Rice, R L; Rusnak, J M; Yokokawa, F et al. (1997) A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation. Biochemistry 36:15965-74
Lazo, J S; Li, T; Woo, E S et al. (1997) Chemical synthesis and biological activity of a novel fluorescent etoposide derivative. Biochem Pharmacol 53:715-22

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